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Chronic opioids suppress gastrointestinal motility, leading to constipation, bacterial overgrowth, and impaired nutrient absorption, especially calcium and vitamin D

With a growing number of patients using these medications for diabetes or to meet certain optimization goals before undergoing hip and knee reconstructive surgery, our aim was to establish evidence-based guidelines on when to discontinue these to enhance patient safety and surgical success. Study Data The study authors used the TriNetX Research Network, a multi-institutional national aggregated database, to identify patients who underwent TKA or THA between January 1, 2018, and January 1, 2023

But higher doses = higher costs + more side effects

Most compounding pharmacies specify refrigerated storage with limited room temperature exposure