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10.1038/s41419-020-03046-z 34 GuoL.LiangZ.YangL.DuW.YuT.TangH.et al (2021)

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however, those on high cholesterol diet presented worse glucose lowering responses to exendin-4 versus chow-fed mice (Figure 1A, B), an effect that was maintained when normalised to the corresponding vehicle control (Figure 1C)

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Oxidation can still occur if the vial isn't properly sealed (oxygen exposure oxidises the copper ion), but the rate is negligible in vacuum-sealed or nitrogen-purged vials