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Emerging data have shown that H 2 rich water has beneficial effects on oxidative stressrelated diseases such as cancer, arteriosclerosis, diabetes, neurodegenerative diseases and the side effects of haemodialysis.5 Moreover, it was reported that H 2 treatment resulted in significantly improved gastrointestinal (GI) transit, protected organs from tissue damage induced by ischaemia reperfusion and effectively ameliorated stressassociated gastric mucosal damage via its antiinflammatory, antioxidant and antiapoptotic effects.6, 7, 8 A new technology based on electrolysis of water has been suggested for clinical amelioration of several pathologies

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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 30% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

prescribing information, including warnings and renal considerations

EBioMedicine 18:261273 Nieoullon A, Canolle B, Masmejean F, Guillet B, Pisano P, Lortet S (2006) The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse