Specific warning signs that require prompt medical assessment include: Symptoms suggesting nocturnal hypoglycaemia (night sweats, palpitations, confusion upon waking) Signs of pancreatitis (severe, persistent abdominal pain that may radiate to the back, accompanied by vomiting) [16] [1] Other severe gastrointestinal complications (persistent vomiting, signs of dehydration) Mental health concerns such as significant anxiety, depression, or mood changes Patients with pre-existing sleep disorders, such as sleep apnoea or insomnia, should inform their healthcare provider before starting Wegovy, as weight loss may improve these conditions but the medication could theoretically interact with existing sleep problems

Digestive Issues Women with Lipedema already have higher rates of: IBS Constipation Bloating SIBO (small intestinal bacterial overgrowth) Slow digestion GLP-1s slow gastric emptying even further, which can increase: Constipation Gastroparesis Reflux Nausea If digestive issues are present, they ideally should be addressed before starting GLP-1s
If you are experiencing persistent fatigue, its important not to self-diagnose
Until stronger data emerge, clinicians must carefully balance potential benefits, safety considerations, and economic impact when considering therapy beyond traditional BMI criteria
Gulec S, Anderson GJ, Collins JF