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In general, BCRP substrates share a same set of molecular properties as that of substrates to P-gp and other efflux pumps (Begley 2004, Kunta and Sinko 2004, Takano et al

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This enhancement of neurotrophic signalling leads to rapid improvements in mood and cognitive flexibility, aligning with the neuroplasticity-based hypothesis of MDD, which posits that MDD arises from widespread deficits in neuronal plasticity and connectivity [229]

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