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An important finding from animal studies: the minimally effective weight-based dosages determined in rats (2.5-5 ml per kg) are considerably higher than typical human clinical doses

In tobacco BY-2 cells, sphinganine or dihydrosphingosine (d18:0, DHS) induce a calcium dependent PCD and trigger H 2 O 2 production via the activation of NADPH oxidase(s)

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However, as cytokine-mediated tissue damage can compromise gas exchange and transport, it is essential that pulmonary immunity is tightly controlled, enabling pathogenic clearance and the prompt restoration of homeostasis, while simultaneously avoiding unnecessary excessive and chronic inflammatory responses [20]

& Moran, S