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Degradation of B12 under Experimental Conditions Degradation of B12 to inactive byproducts in multivitamins isnt likely to pose a problem for vegans with normal digestion because 1) B12 transport proteins will protect it once dissolved, 2) intrinsic factor selects for active B12 over inactive analogs, 3) only a small percentage of B12 in multivitamins is typically degraded, and 4) manufacturers now typically add overages to supplements to cover degradation over the shelf-life of a supplement in order to be compliant with requirements