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In fructose-fed mice, a decrease in intestinal SERT protein leads to extracellular serotonin aggregation, resulting in transmural transport, decreased occludin expression, and increased intestinal permeability

The forward and reverse primers used for IFN-, TNF-, and IL-6 quantification were described previously [19, 46]

Clinical Effectiveness Clinical studies have shown that semaglutide significantly reduces body weight and improves glycemic control when used consistently, along with diet and exercise

Mean baseline body weight was 106.3 kg, and mean BMI was 38.3 kg/m2

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