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T- cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin

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Nature New Biology

Moreover, 5 mg/kg 3-bromopyruvate (glycolysis inhibitor) in a mouse with arthritis induced by K/BxN mouse serum reduces clinical score, proinflammatory cytokines in the joint, inflammatory cell infiltration, joint destruction, and cartilage damage 27 , which has made it possible to consider glycolysis pathway inhibition as a potential pharmacological target for RA 29

However, some individuals may experience mild side effects or should exercise caution in specific circumstances