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2 Material and methods 2.1 Study subjects This was a prospective cohort study

The pattern below is a rough composite from compound-level research and protocol notes not a guarantee of outcomes

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4 weeks (300500 mcg/day): ~12 vials 8 weeks (300500 mcg/day): ~23 vials Advanced (500750 mcg, 2/day): more vials needed Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 8 weeks (once daily): ~56 syringes 8 weeks (twice daily): ~112 syringes Bacteriostatic Water (10 mL bottles) Use 3.0 mL (gradual) or 2.0 mL (advanced) per 10 mg vial for reconstitution

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