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[15] [16] For weight management, FDA-approved agents include semaglutide 2.4 mg (Wegovy), tirzepatide (Zepbound), and liraglutide 3 mg (Saxenda), with weight reduction varying by medication (typically 5-15% with liraglutide, 15-20% with semaglutide, and up to 20-25% with tirzepatide)

Both companies provide lower dose options of their products that are not included in this summary

Most patients at our Houston clinic lose between 13 pounds per week

The most commonly reported side effects of Rybelsus include: Gastrointestinal disturbances nausea (very common, affecting more than 1 in 10 patients), vomiting, diarrhoea, abdominal pain, constipation, and dyspepsia (common, affecting up to 1 in 10 patients) Decreased appetite (common) often contributing to weight loss Hypoglycaemia (common) particularly when used in combination with insulin or sulfonylureas

Triple, quadruple and quintuple agonists are now in development, as is an expanded range of oral formulations