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doi: 10.1200/JCO.2012.44.8738 11

Short-term results are real, but long-term use can bring side effects and dependency

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The DAC version produces a flatter, more constantly elevated IGF-1 curve compared to the spikier, more physiologic pattern of no-DAC

Accordingly, molecules with a good affinity and selectivity for these receptors/transporters can be explored as brain-targeting agents