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Tirzepatide has demonstrated cardiovascular safety in clinical trials, with benefits for patients with type 2 diabetes and established coronary disease

Developed originally for type 2 diabetes management, semaglutide gained widespread attention after clinical trials revealed that patients were losing significant amounts of weight as a secondary benefit

Tirzepatide may be appropriate for adults with a BMI of 30 or higher, or a BMI of 27 or higher with a weight-related condition such as high blood pressure, type 2 diabetes, or sleep apnea

Retatrutide appears to push the science even further

Semaglutide, tirzepatide, and eventually retatrutide each have a role, but no single drug is right for every person