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Critical Akt substrates include mTOR, which when activated drives protein synthesis, and FoxO transcription factors, which when phosphorylated by Akt are excluded from the nucleus, preventing their transcriptional activation of atrophy genes

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It also can lead to lower testosterone levels which increase an increase in aromatase leading to high estrogen levels high estrogen levels lead to fat, particularly in the belly

In a public advisory on Wednesday, Health Canada said that as interest grows in GLP-1 products for weight loss, "some people may turn to unauthorized or counterfeit products, which could pose serious health risks because they have not been assessed by Health Canada for safety, effectiveness, or quality." The versions of the medications authorized for use in Canada are semaglutide (Ozempic and Wegovy injections and Rybelsus oral tablets) and tirzepatide (Mounjaro and Zepbound injections)