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A second distinction involves the anti-inflammatory pathway

When side effects occur, many users report that symptoms are temporary and resolve after treatment adjustments or discontinuation

Bacteria from previous injections can contaminate the vial if using the same needle repeatedly

To perform the procedure, a vacuum hand piece is placed over the dimpled tissue through which the surgeon will deliver a local anesthetic

2.5 Quality assessment and risk of bias In line with PRISMA guidelines, the assessment of methodological quality was conducted to evaluate the strength of evidence, recognising that methodological limitations may introduce bias