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Lastly, we identified a group of systemic comorbidities related to overall health that were commonly used as exclusion criteria (Fig

212 Another mechanism of HFD-induced liver metastasis is the upregulation of NOD-like receptor C4 (NLRC4), which further induces M2-like macrophage activation and IL-1 processing

Natural differences in MC1R can affect how well this pathway responds, influencing pigmentation, UV sensitivity, and how efficiently the skin builds its protective response

Proteins were pelleted by centrifugation (5500 g at 4 C for 10 min), the pellet was washed three times with ice-cold precipitation solution and once with ice-cold acetone

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