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Histamine is a hormone involved in digestion, immune & nervous system function

Nutrients 9(10):1132 Davis AR, Webber CL, Fish WW, Wehner TC, King S, Perkins-Veazie P (2011) L-citrulline levels in watermelon cultigens tested in two environments

LY3298176, a novel long-acting GIP/GLP-1 coagonist, shows enhanced activity on weight loss and energy utilization whilst maintaining its efficacy for glycaemic control

Off-label use for weight loss is not advisable without physician guidance

Oral Formulations oral GLP-1 are 1) much easier to manufacture at scale compared to the current injectable GLP-1 drugs, 2) much simpler to distribute globally, given no need for cold-chain storage, 3) more attractive for needle-phobic patients who avoid the injectable GLP-1 drugs currently available, and 4) better suited to long-term maintenance therapy, given what we expect will be lower pricing (and lower costs) for orals compared to injectable GLP-1 drugs