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Additionally, ketogenic diets, in theory, can also have a similar impact to calorie restriction, by downregulation of IGF-1 and insulin, promoting PI3K inhibition function, and through increased exposure to oxidative stress for the tumour cells [148,149,150]

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Semaglutide (the active ingredient in Wegovy) can trigger diverse side effects as your metabolism adapts, and chills or cold sensations represent a rare but documented response in some patients