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2b) and cysteine starvation (Supplementary Fig

Inhibiting system Xc reduces GSH production, thereby diminishing the activity of GPX4 and leading to ROS accumulation, ultimately driving ferroptosis in CRC cells [61, 69-72]

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Thus, a systematic review of the efficacy of GLP-1RAs in terms of their effect on the underlying pathology of AD and improvement of cognitive functions, which included 6 articles that met the criteria (4 randomized control studies and 2 protocol studies) [53], indicates that GLP-1RA therapy in AD did not alter -amyloid and tau protein biomarkers and did not improve cognitive abilities, but demonstrated potential metabolic and neuroprotective benefits