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However, in patients treated with diclofenac and glucocorticoids, the risk of peptic ulcer and gastrointestinal bleeding may increase, so special attention should be given in case of prolonged treatment, even in the absence of serious gastrointestinal symptoms

The GSH/GPX4 node is the crucial regulator of ferroptosis The GSH system, as a lipid peroxide scavenger, has attracted much attention as a potential therapeutic target for ferroptosis

The Intestinal Barrier Your gut lining is made up of enterocytes (nutrient-absorbing cells) and supported by mucus-producing goblet cells, immune-releasing enterochromaffin cells, antimicrobial Paneth cells, and M cells that survey for invaders

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Site-directed mutagenesis experiments show that cysteine-553 in human GLCLC is involved in heterodimer formation between the catalytically active GLCLC and the auxiliary, activity-enhancing GLCLR unit, which likely occurs through a disulfide bond [139]