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Thus, having a certain percentage of HbS stabilized in the oxygenated state may prevent sickling thereof (Figure 1), a drug that binds covalently to the a-globin and stabilizes Hb in the oxygenated form (Vichinsky et al., 2019)
doi: 10.1016/j.neuron.2019.02.038 97 GazestaniV.KamathT.NadafN
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Yin Y, Choi SC, Xu Z, Perry DJ, Seay H, Croker BP et al (2015) Normalization of CD4+ T cell metabolism reverses lupus