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Most of this information came from the Cleveland Public Library which houses Little's chess scrapbooks and manuscripts
Berberine dosages have not been formally established, but clinical studies use a dose range between 500mg and 2,000mg daily
Treatment duration proves critical variable where longer courses create more durable changes - users completing 2-3 month treatments typically maintain 20-40% of peak benefits long-term, 4-6 month treatments sustain 40-60% of improvements, and 6-12+ month courses preserve 50-70% of maximum benefits potentially indefinitely
Toki et al., 2021)
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