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Early case series and open-label studies support feasibility and biological plausibility, whereas randomized trials show mixed clinical signals, highlighting donor-dependent effects, protocol heterogeneity (preconditioning, route, dose/frequency), and the need for engraftment-aware endpoints [252,253,254,255]

Structure, function, and regulation of mitofusin-2 in health and disease

It reduces pro-inflammatory factors and ROS generation, and promotes HO-1 expression, suggesting its potential as an anti-inflammatory and antioxidant agent