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Given the importance of purine-containing molecules for survival, vertebrates, including humans, have developed robust systems for synthesizing sufficient purine nucleosides for their metabolism using readily available materials (such as glucose, glycine, and glutamine), as well as recycling purine nucleosides from throughout the body or from the diet

Unlike single-mechanism ingredients that target just one aspect of aging skin, these compounds work through multiple pathways simultaneously, addressing collagen synthesis, wound healing, antioxidant protection, and skin barrier function all at once

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doi:10.3390/cosmetics2030236 6

Patients should be counseled to use a nonoral contraceptive method or add a barrier method for 4 weeks after initiation and for 4 weeks after each dose escalation