The treatment policy estimand evaluated the treatment effect among all participants, regardless of treatment discontinuation or rescue intervention, while the trial product estimand addressed the average treatment effect in all participants assuming adherence to the treatment protocol
Someone on a microdose tirzepatide protocol losing weight gradually would face substantially lower risk than someone on the maximum dose experiencing rapid, dramatic weight loss
Turning to another popular GLP-1, Mounjaro (tirzepatide), studies report 20-25% total body weight loss at maximum doses after 72 weeks
Lower doses may clear slightly faster, while the highest dose of 2.4 mg used for weight loss takes the full 5 weeks to disappear
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