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Areas of low shear stress trigger proatherogenic responses such as increased permeability, production of ROS, activation of NF-B, and upregulation of adhesion molecules that attract leukocytes [462]

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Mechanisms: Its activity includes antioxidant modulation and fibroblast activation, contributing to improved tissue strength, elasticity, and resilience

Having demonstrated that GLP-1MK-801 and GLP-1inactive MK-801 display comparable pharmacokinetic properties in vitro, we next assessed their respective in vivo efficacies against the parent GLP-1 analogue in DIO mice