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Iron overload reduces CaV1.3-dependent L-type Ca 2+ currents ( 2+ leaks through the Ca 2+ release channels (62), sarcoendoplasmic reticulum Ca 2+ -ATPase activity is inhibited, the sodium-calcium exchanger currents are elevated (63), and L-type calcium channels are reduced (64, 65)

Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions