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Downstream cellular signal transduction pathways induced by HGF Compared with the untreated control of the SCLC NCI-H69 cells, HGF stimulation at 40 ng ml 1 for 7.5 min caused an induction of phosphorylation of the following phosphoprotein phosphosites (Figure 2C): adducin- [S724] (146%), adducin- [S662] (125%), CREB [S133] (143%), ERK1 [T185/Y187] (449%), ERK1/2 [T202/Y204] (558%), ERK2 [T185/Y187] (289%), MAPKK (MEK) 1/2 [S221/S225] (183%), MAPKK (MEK) 3/6 [S189/S207] (118%), RB [S612] (146%), RB1 [S780] (197%), JNK [T183/Y185] (163%), STAT3 [S727] 139%), FAK [Y576] (132%), FAK [S722] (123%), FAK [S910] (165%), p38 -MAPK [T180/Y182] (136%), and AKT1 [S473] (166%) and [T308] (207%)