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Interestingly, the complement system also impacts T-cell immunity during the induction, effector, and contraction phases of an immune response

Alterations of the Krebs cycle and OXPHOS in renal diseases Several studies showed that the persistence of mitochondrial bioenergetics impairment is a key process in the genesis of AKI and CKD progression (Forbes and Thorburn 2018

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However, these cells are highly sensitive to their environment, and elevated oxidative stress can physically trigger them to degranulate inappropriately

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