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Even at lower levels, NAPQI can deplete glutathione in the brain and create oxidative stress

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These are research pairings, not dosing recommendations

Unlike apoptosis, which involves caspase activation and nuclear fragmentation, ferroptosis is initiated by iron accumulation and lipid peroxidation, resulting in membrane rupture without caspase involvement ( This review aims to comprehensively analyze recent advances in understanding ferroptosis mechanisms in CHD and evaluate emerging clinical intervention strategies

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