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Structure refinement was done using Refmac 57 and Buster 36 , and model correction and building was done using Coot 0.9.6 35

The homeostatic blood pressure regulation is particularly noteworthy

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Studies have investigated NNMT inhibition in the context of obesity, metabolic dysfunction, lipid accumulation, and energy-expenditure models, with research also exploring effects on adipocyte differentiation and methylation pathways