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Stomach Pain and Bloating: As digestion slows down, food remains in the stomach longer, which can lead to a feeling of fullness, bloating, and mild abdominal cramping

That kind of evidence can show links, but more research including placebo-controlled trials are needed to confirm the findings

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On May 1, 2025, Eli Lilly announced that it withdrew its FDA application for Zepbound (tirzepatide) for the treatment of HFpEF in patients with obesity, stating that the FDA requires an additional confirmatory trial to support the application