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Interestingly, the liposome without any targeting ligands conjugation could also serve as an external stimuli-controlled nanosystem for brain-targeted drug delivery
Oxyntomodulin is a biased agonist relative to GLP-1 4 , and forms distinct and more dynamic interactions with the GLP-1R, particularly with residues at the base of the peptide binding cavity that is located above the conserved central polar network that is important for receptor activation
Based on the single dose tested for 2 , the estimated ED 50 is below 100 mg/kg
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