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Key findings: Significant weight loss despite GLP-1 shortages Despite challenges that impacted GLP-1 medication accesssuch as insurance coverage limitations and supply shortagespatients in the Calibrate program achieved significant weight loss

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[cited 2025 Dec 5]

"We now have more than two years of experience using these medicines for weight loss, and what we're seeing is that, in some cases, one drug is better, it has fewer side effects, and perhaps greater efficacy than the other," Aronne said

Growth hormone naturally declines with age, and some practitioners hypothesize that restoring GH levels could support lean muscle preservation during weight loss