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The binding of S100A12 to the RAGE V domain increases cellular inflammatory response to oxidative stress (150) and participates in the pathogenesis of psoriasis ( Figure 3 )

Key animal studies (especially in Syrian hamsters, and ideally with hamster-derived CP for matched antibody Fc regions) and human clinical safety and efficacy results for CP are now emerging contemporaneously

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Intern Med 45 : 127134 Murray CD et al

276 By contrast, Fagher et al 308 found no subjective improvement in fatigue in 14 patients treated with L-carnitine for 6 weeks