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Additionally, as detected with a Seahorse XF analyzer, we found that the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were both decreased in ACTL6A-KD cells (Supplementary Fig 2d, e)

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doi: 10.1016/j.heliyon.2023.e18991 7 AndersH

This pathological state manifests as brain hypoxia, fluid metabolic disorders, and abnormal neural signal transmission, which highly corresponds to the cerebral tissue edema and microcirculation disorders described in modern medicine