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How B12 Deficiency Affects Your Metabolism and Energy Now, while B12 doesn't directly cause weight gain, a deficiency can certainly have an indirect impact on your body's energy levels and, consequently, your activity and metabolism

For B12 deficiency, a typical injection dose is 1,000 micrograms (mcg) once a week for 4 to 8 weeks, then monthly

Always confirm dosing with your provider and pharmacy label

The optimal frequency depends on your goals, schedule, and tolerance for injection frequency

total cumulative food intake in control and treated DIO mice was 28.1 1.2 g and 26.2 1.4 g, respectively (Figure 5B, inset)