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Ligands were then added, after which signal was repeatedly recorded for 30 min

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Hypoxia-inducible factor-1 (HIF-1) also exhibits dual regulation: during acute hypoxia, it stimulates eNOS expression to ensure adequate NO production but may suppress eNOS in chronic hypoxia, causing maladaptive vascular changes (McQuillan et al., 1994

Front Cell Infect Microbiol 2021;11:595575.ArticlePubMedPMC 97