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2.6.2 Sparse partial least squares discriminant analysis (sPLS-DA) We also employed the sPLS-DA method, implemented in the R package mixOmics (v6.6.2) (Rohart et al., 2017), on aggregated ASV, genus, TIGRFAM and subrole data with the purpose of identifying finer subsets of discriminant features in the data set

Using erastin-treated A549 cells, we measured intracellular Fe 2+ , ROS, lipid peroxide, glutathione, glutamate release into the extracellular space, and cystine uptake

These represent fundamentally different biological scenarios even though both involve the same molecular players

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