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Selenium toxicity can occur with excessive intake [62]

probiotics have been shown to lower the serum levels of Antinuclear Antibodies (ANA) ( Furthermore, vitamin D also showed significant inhibition of NF-B pathways (181), and a regulatory effect regarding cytokine production, thus it inhibits proinflammatory cytokines in SLE pathogenesis, including IFN-, IL-17, IL-23, IL-6, and TNF- (182184), while stimulating anti-inflammatory cytokine production like IL-10 and TGF- (185, 186)

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Science (2011) 334:67883

It's worth being realistic here: Topically applied Hydrolyzed Collagen conditions the upper layers of skin rather than rebuilding the structural collagen deep in your dermis (the wrinkle-and-firmness benefits people associate with Collagen mostly come from oral supplements in studies, not topicals)