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For quantitative synthesis, a total of 46 studies were ultimately included (2262)

Funding The work was supported by Natural Science Foundation of Liaoning Province (2019-MS-075), Liaoning Revitalization Talents Program (XLYC1807124), Dalian Technology Innovation Program (2019J13SN109) and Health Commission of Dalian (1811014)

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On the base level, these treatments target the melanin pigment, responsible for skin color, and reduces its production