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Lipid dyshomeostasis interacts with several AD pathogenic pathways, including amyloidogenesis, mitochondrial dysfunction, oxidative stress, neuroinflammation, and myelin degeneration (Yin, 2023
In agreement with PHGDH KO mice, PSAT1 knockdown impairs glucose and insulin tolerance (26)
Signs of excessive sodium: Swelling in hands, feet, or face Persistent thirst despite adequate fluid intake Blood pressure increases (monitor if you have hypertension) For most GLP-1 users without kidney or heart conditions, 2,000-3,000mg sodium daily from electrolytes plus food is safe and beneficial
In terms of mechanism, the cross-talk between IGF1R and carcinogenic factors, including integrins, focal adhesion kinase, and the RACK1 scaffolding protein enhanced the motility and migration of cells (Tressler et al., 1993