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Thus, bacteria have evolved conserved pathways for detoxification of formaldehyde and methylglyoxal that involve LMW thiols

A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]

Yamashita Y, Suzuki C, Uchiyama Y, Nagata S

A hydrogel microsphere with micelle microfluidic properties contains a ketone enol thiol-bridged nanoscale secondary structure, which downregulates TfR1 expression through metal chelation and increases the expression of CDGSH iron sulfur domain-containing protein 1 (CISD1), thereby restoring mitochondrial iron homeostasis and promoting cartilage repair (170)

Consistency matters more than speed