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Mazdutide is a dual GLP-1/glucagon agonist developed by Innovent Biologics, primarily studied in Chinese populations, showing weight loss of 14-18% in clinical trials

Adverse events are rare but include mild gastrointestinal upset and allergic reactions

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Most patients undergo surgery combined with adjuvant and/or neoadjuvant chemotherapy, depending on the stage of the disease, followed by a long course of SERM if the cancer cells express hormonal receptors