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In a Caenorhabditis elegans model, valproate inhibited behaviors associated with inositol triphosphate (IP3) and DAG, which was countered by administration of phorbol ester, a pkc activator

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McNulty PH, Sinusas AJ, Shi CQ, Dione D, Young LH, Cline GC, Shulman GI (1996) Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia