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Preclinical studies in rodents have shown an association between GLP-1 receptor activation and thyroid C-cell changes, although a direct causal link in humans has not been established, and UK/EU SmPCs for authorised GLP-1 RAs do not list MTC or MEN2 as a formal contraindication

While Semaglutide supports caloric control and weight management , Tirzepatides dual pathway may provide an advantage in fat oxidation and metabolic efficiency

Increased expression of glucagon-like peptide-1 receptors in psoriasis plaques