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Exogenous administration of neurotrophic factors can promote nerve regeneration and improve functional outcomes in experimental models of DPN

Common maintenance approaches include staying at the dose where you stabilized (often 1.0 to 1.7 mg), reducing by one dose level from your peak (e.g., from 2.4 mg to 1.7 mg), or finding the minimum dose that prevents weight regain while minimizing side effects

Effect of Glutathione Infusion on Leg Arterial Circulation, Cutaneous Microcirculation, and Pain-Free Walking Distance in Patients With Peripheral Obstructive Arterial Disease: A Randomized, Double-Blind, Placebo-Controlled Trial 23

Preclinical results have shown that P-15-containing bone graft substitutes could facilitate bone healing and regeneration [118]