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For example, a 2024 systematic review and meta-analysis of clinical trials concluded that GLP-1 agonist treatment led to significantly greater improvements on depression rating scale scores compared to control treatments (placebo or other drugs) in adults (Chen et al., 2024)

A., Sherr, A., Shirin, S., Solodkina, G., Morales-Tapia, E., Wolf, B., Lifshitz, Y

This is where B12 benefits can come into play