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The sprays can cause nausea, vomiting, high blood pressure and even changes in mole shape and size, the Chartered Trading Standards Institute (CTSI) said

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Heart-rate escalation peak vs steady-state mean SURMOUNT-1 week-72 pulse +0.6/+2.3/+2.6 bpm

doi: 10.1007/s12275-013-3052-6 2 AhmadS.AlfouzanW

And listen to the problem one FDA official laid out at that meeting