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The compound activates HGF/c-Met signaling in hippocampal and cortical regions at picomolar to nanomolar concentrations, suggesting efficient distribution to the brain regions most relevant to learning and memory

[1] Unlike amphetamine abuse, where drug tolerance necessitates escalating doses to achieve the same effect, tolerance to clinically relevant doses of amphetamine plateaus after the initial titration period, and "drug holidays" (i.e., temporary treatment discontinuation) are not required to prevent the development of tolerance

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On the other hand, rats treated with BSO 4 mmol/kg of body weight twice a day showed significantly decreased levels of GSH and enzymatic activity of CAT, SOD, and GPX in blood and erythrocytes, as well as increased levels of MDA

& Hourvitz, A